In this study it has been analyzed the role of collagenase analog on the triple helical structure of collagen in wound healing through Insilco method. The tools used are i) The PDB RCSB to get the 3D structure of the protein Collagen. ii) The drug bank to get the drugs for the wound healing disease. iii) The NCBI to get the drug collagenase chemical structure. iv) The NCI to get the analogs for the drug collagenase v) The hex to perform docking of collagen receptor and collagenase ligands vi)The Swiss PDB Deep Viewer to find the interacting amino acids from the docked complex. vii)The CAST P to find the active sites in the protein collagen. The analogs of collagenase drug acts on the amino acids such as proline and hydroxyproline to inhibit their role in the triple helical structure of collagen protein and to release fibrin or fibronectin which prevents blood loss in wound. It is finally conclude that in the five analogs of collagenase drug the most effective analogs which are acting on the Proline and hydroxyproline that are responsible for forming the triple helical structure of the collagen protein, can be cleaved by the action of three analogs like 1-bromo-2,5-pyrrolidinedione, 2-ethyl-1,2-diphenyl-1butanol and 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.
Wound healing, Collagen, Collagenase, Fibronection, Analogs
