1Department of Biotechnology, Meerut Institute of Engineering and Technology, N.H. 58, Delhi-Roorkee Highway, Baghpat Road Bypass Crossing, Meerut-250005, UP, India.
Deleted in Colon Cancer (DCC) is a tumor suppressor gene, which is deleted in 70% of Colon cancers. Here, we investigate the protein product of DCC in much detail towards a better understanding how it leads to cancers. The protein sequence was retrieved through NCBI. Three mutations in protein sequence have been identified that are associated with colon cancer. Domain analysis shows that all the three mutations are present in functional domains. It was concluded from the results of physicochemical and structural analysis that the change of a single amino acid disrupts the structure of domain that leads to tumorigenesis. The analyses were performed using various
Deleted in Colon Cancer (DCC), NCBI, BLASTP, Multiple Sequence Alignment (MSA), PROTPRAM and SOPMA.
