Application of Response Surface Methodology for Extraction of Jute Leaf Phytochemicals

Jute is a rich source of phytochemicals and exploitation of this resource can open a new horizon. Although, innumerable number of literature are available for extraction of phytochemicals from different plant sources, but proper extraction methodology for jute leaf could not be standardized. Therefore an attempt has been made to develop a chief and effective methodology for extraction of jute leaf phytochemicals. Response surface methodology (RSM) is one of the popular methods in the development and optimization of drug delivery systems. Based on the principles of design of experiments (DOE), the methodology involves the use of various types of experimental designs, generation of polynomial mathematical relationships and mapping of the response over the experimental domain to select the optimum formulation. The current study aimed at developing and optimizing a yield of jute leaf extract through solvent extraction techniques using computer-aided optimization technique i.e. Central composite design (CCD) with constraints on the efficient extraction of jute leaf phytochemicals. Response surface methodology was successfully optimized the total yield extract of jute leaf which in other way induced to extract the total phenolic content (TPC).