2Daniel Baugh Institute of Bioinformatics and Functional Genomics, Department Of Pathology, 1020 Locust Street, Room 320 Ajah, Thomas Jefferson University, Philadelphia, 19107, PA, USA
11020 Locust st, Jefferson Alumni Hall, Room no. 320A, Philadelphia, PA, ZIP 19107, USA
*Correspondence to E-mail: vikya08@yahoo.com
Online published on 3 April, 2014.
System biology emerging from year 2000 onwards in biomedical sciences is multi disciplinary approaches focus on complex dynamics interaction with in biological system. Alcohol and other drugs are potent cause of liver failure in USA and Worldwide. We describe system biology approaches a potential tool for identifying cell signaling pathways and co expressed genes involved in liver toxicity induced by reactive oxygen species, free fatty acids, and TNFα in liver hepatocyte, kupffer cell and stellate cells. System biology approaches analyzed multiple omics data i.e. Phenomics, Genomics, Epigenomics, Lipidomics, Metabolomics, Transcriptomics and Proteomics etc. to understand gene expression, metabolic profile, toxicity profile to predict and validate or characterized gene targets for liver toxicity.
Biology, biomarker, liver disease
