To Evaluate the Efficacy and Safety of Dexmedetomidine on Hemodynamic Stability in Patients Undergoing Laproscopic Cholecystectomy

Peritoneal insufflation of intra-abdominal pressure >10 mmHg induces a significant alteration of hemodynamics. Use of α-2 adrenergic agonists Dexmedetomidine significantly reduces hemodynamic changes and anesthetic requirements as it has sedative, analgesic, and anxiolytic properties.

100 patients of ASA I-II undergoing laparoscopic cholecystectomy were randomly allocated into two groups of 50 patients each. Group I patients received dexmedetomidine infusion at 0.2μg/kg/hr and Group II patients received normal saline infusion at 0.2μg/kg/h starting after intubation and continued till peritoneal deflation. Parameters noted were pulse rate, mean arterial pressure, oxygen saturation, EtCO₂ and isoflurane requirement.

In dexmedetomidine group, the haemodynamic response was significantly attenuated. The anaesthetic requirement was also less with dexmedetomidine group without any desaturation.

Dexmedetomidine infusion in the dose of 0.2μg/kg/h effectively attenuates haemodynamic stress response to pneumoperitoneum during laparoscopic surgery.