1Assistant Professor, Department of Anaesthesiology & Critical Care, Rural Medical College, Pravara Institute of Medical Sciences, Loni
2Senior Resident, Department of Anaesthesiology & Critical Care, Rural Medical College, Pravara Institute of Medical Sciences, Loni
3Professor, Department of Anaesthesiology & Critical Care, Rural Medical College, Pravara Institute of Medical Sciences, Loni
4Professor & Emeritus, Department of Anaesthesiology & Critical Care, Rural Medical College, Pravara Institute of Medical Sciences, Loni
*Corresponding Author: Email: aksnsdr@gmail.com
Online published on 9 June, 2016.
Preanesthetic medication forms an integral part of anaesthetic management. Pharmacological and nonpharmacological techniques are tried to achieve anxiolysis and better hemodynamic stability. Clonidine is alpha 2 agonist and acts on central nervous sytem. It is adminstered in various route and oral route is one of them. This study has been designed to study the effect of oral clonidine on perioperative hemodynamics.
To evaluate beneficial effects of oral clonidine in attenuating the haemodynamic responses and comparing with placebo in patients undergoing surgeries under general anaesthesia.
Randomized double blind study.
Two hundred patients were enrolled in this study and studied for 2 years. Randomization was carried out. Four groups, including 50 patients per group were created. Group I (Placebo) received oral tablet ranitidine 150 mg, Group II C2, C3 and C4received oral clonidine 2 μg/kg, 3μg/kg and 4μg/kg body weight respectively. Sedation, anxiolysis and hemodynamic changes were recorded.
The statistical significance for categorical variables was determined by chi-square test. For continuous variables two sample t-test was applied. For intra group comparison paired t-test and for inter group comparison unpaired t-test was used. Results were expressed as Mean ± SD (standard deviation). A P value < 0.05 was considered statistically significant.
No statistically significant differences concerning demographic data between the groups of patients computed. A significant difference observed with respect to sedation and anxiolysis between all the four groups. The HR response between clonidine (2 μg/kg, 3μg/kg and 4μg/kg) and placebo was very significant at all times (p<0.001) showing a favorable response towards attenuation of HR. The SBP, MAP and DBP response between clonidine and placebo is significant at all times. When compared to clonidine (2 μg/kg, 3μg/kg and 4μg/kg) group the requirement of MAC of Isoflurane in placebo group is higher.
Administration of oral clonidine preferably 4μg/kg, as pre-medicant results in improved perioperative haemodynamic stability and Isoflurane sparing effect.
Anxiolysis, Clonidine, Hemodynamic response, Oral premedication
