1Assistant professor, Anaesthesiology, Stanley Medical College and Hospital
2Assistant professor, Anaesthesiology, SRM Medical College and Research Centre
*Corresponding Author: E-mail: kv_anand78@yahoo.co.in
Online published on 9 June, 2016.
Ropivacaine has a reduced risk of cardiotoxicity, neurotoxicity, and rapid recovery of motor function. Postoperative pain relief is an important issue with Ropivacaine. Dexmedetomidine which is a highly selective α-2 adrenergic agonist with eight times greater affinity for receptors than clonidine decrease the requirements of analgesics and augment the effects of local anaesthetics
Compare the analgesic efficacy of intrathecal isobaric 0.75% Ropivacaine with the combination of isobaric 0.75% Ropivacaine and Dexmedetomidine.
A prospective randomized double-blinded study.
100 patients were selected and allocated in two groups randomly.
• ASAI & II
• Either sex
• 18–60 years for lower limb Orthopaedic surgery
• Patient refusal
• Patients who had contraindications for spinal anaesthesia
• Allergy to local anaesthetics
• Cardiac disease
• Hypertension Patients were divided into two following groups randomly by lot method.
• Group R: Received 3ml volume of 0.75% isobaric ropivacaine and 0.5ml normal saline.
• Group D: Received 3ml volume of 0.75% isobaric ropivacaine and 5μg dexmedetomidine in 0.5ml normal saline
Ropivacaine vs. plain 0.75% isobaric Ropivacaine given intrathecally in patients who underwent lower limb orthopedic surgeries.
The following observations were made:
The addition of 5ug Dexmedetomidine to 0.75% Ropivacaine significantly prolonged the duration of analgesia and the time to demand analgesia.
The addition of dexmedetomidine intrathecally produced sedation that was arousable for many hours compared to plain ropivacaine group
The incidence of side effects such as hypotension and bradycardia were more in patients who received dexmedetomidine But shivering was greatly reduced in dexmedetomidine.
No episode of respiratory depression was noted in both the study groups which are more common with opioids.
Ropivacine, Dexmedetomidine, Intrathecal, Isobaric
