To evaluate role of gabapentin as a preemptive analgesic in patients undergoing modified radical mastectomy

Pre-emptive analgesia involves the introduction of an analgesic regimen before the onset of noxious stimuli, with the goal of preventing sensitization of the nervous system to subsequent stimuli that could amplify pain. We use Gabapentin as a preemptive analgesic and is more effective than conventional regimens in patients undergoing modified radical mastectomy.

50 adult female patients of ASA grade I and II were divided randomly in to 2 groups(n=25). Study Group: Group G received Tab. Gabapentin 600mg orally with sips of water 1 hour before surgery. Control Group: Group C Placebo group.

Mean Duration of analgesia is statistically highly significant in Group G.(p <0.0001). Mean VAS was higher in Group C compared to Group G(p<0.0001) statistically highly significant at 1, 2, 4hr post-operatively. Incidence of Sedation, Nausea and vomiting-Higher in Group G. In our study, further need of mean rescue analgesic doses during 24 hrs. In Group G is 1.44 doses and in Group C is 2.52 doses which statistically highly significant in Group C.(p <0.0001)

Preemptive Tab. Gabapentin 600mg. prolonges postoperative analgesia and reduces rescue analgesic requirement than control group but has more side effect like nausea and vomiting.