Efficacy of dexmedetomidine versus nitroglycerin for maintenance of hemodynamic variables during dental surgeries

Is to find the effectiveness of dexmedetomidine versus nitroglycerin to provide hemodynamic stability during dental surgeries

Forty ASA I and II patients undergoing dental surgeries were randomly allocated into two groups of 20 each: Nitroglycerine (Group NTG) and Dexmedetomidine (Group DEX). Group NTG received infusion of nitroglycerine at a rate of 110 μg/kg/min & group DEX received infusion of dexmedetomidine at a rate of 0.2–0.7 μg/kg/hr after a bolus dose of 1 μg/kg.

There was better control of hemodynamic variables during intraoperative period in dexmedetomidine group in comparison to nitroglycerine group. There was significant difference in mean changes of heart rate and blood pressure from baseline value at all points of study between both the groups except just before the intubation when both the groups were comparable.

Dexmedetomidine was superior to nitroglycerin for maintenance of hemodynamic variables during dental surgeries.