Indian Journal of Clinical Anaesthesia
  • Year: 2018
  • Volume: 5
  • Issue: 2

Oral premedication in children: A randomized study of a combination of oral midazolam, ketamine with atropine vs midazolam and atropine vs ketamine and atropine

  • Author:
  • Ranjan Ramakrishna1, KJ Hemanth2, BV Sunil1,, S Neeta3, Sonal Bhat4
  • Total Page Count: 5
  • Page Number: 261 to 265

1Associate Professor, Dept. of Anesthesiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangaluru, Karnataka, India

2Junior Resident, Dept. of Anesthesiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangaluru, Karnataka, India

3Assistant Professor, Dept. of Anesthesiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangaluru, Karnataka, India

4Associate Professor, Dept. of Anesthesiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Mangaluru, Karnataka, India

*Corresponding Author: Email: drsunilbv@gmail.com.

Online published on 24 September, 2018.

Abstract

Premedication is widely used in pediatric anesthesia in order to provide sedation and anxiolysis. Aim of the study was to compare the effectiveness of combination of low dose oral midazolam and ketamine with oral midazolam or oral ketamine as premedication.

150 childrens between ages 2 and 10 were divided into 3 groups of 50 members each. They received either combination of oral midazolam 0.5 mg/kg and oral ketamine 3mg/kg or oral midazolam 0.5 mg/kg or oral ketamine 6 mg/kg as pre medication. Premedication was given 30 minutes before the induction of anesthesia. Patients also received oral atropine 0.02mg/kg along with the study drug. Sedation and anxiolysis were assessed before giving premedication and at an interval of 10 minutes, 20 minutes and 30 minutes after premedication. Behavior at separation from parents and acceptance or response to venipuncture was also assessed at the end of 30 minutes. Statistical analysis was performed using SSPE computer software version 16. Groups are compared using chi square tests.

We found that oral combination of midazolam 0.5 mg/kg and ketamine 3 mg/kg with atropine 0.02mg/kg offered better sedation [96% children], anxiolysis [76% children], acceptance of parentral separation [80% children] and comfortable venous cannulation [84% children]. We conclude that Combination of oral ketamine, midazolam and atropine is a superior premedicating agent than using these drugs individually

Keywords

Ketamine, Midazolam, Premedication, Pediatric