International Journal of Clinical Biochemistry and Research

  • Year: 2015
  • Volume: 2
  • Issue: 3

Study of Paraoxonase, Catalase, HDL-Cholesterol and Malondialdehyde Levels in NIDDM

  • Author:
  • Anuradha Katti-Suryawanshi1,, Shailaja Avinash Katti2, D.S. Jayaprakash Murthy3, Abdul Kayum Shaikh4
  • Total Page Count: 8
  • DOI:
  • Page Number: 154 to 161

1Assistant Professor, Ashwini Rural Medical College & Research Centre, Maharashtra

2Assistant Professor, Father Mullers Medical College, Karnataka

3Professor & Head, Oxford Medical College, Bangalore

4Professor & Head, Ashwini Rural Medical College & Research Centre, Maharashtra

Abstract

Diabetes Mellitus (DM) is an important cause of morbidity and mortality through its various complications. A decrease in Paraoxonase 1 (PON1) activity in diabetes is associated with occurrence of vascular complications. Our objectives were to estimate PON1 activity, Catalase (CAT) activity and Malondialdehyde (MDA) levels in Non-Insulin Dependent Diabetes Mellitus (NIDDM) cases and controls. We also had an objective to establish possible relationship between PON1, High Density Lipoprotein-Cholesterol (HDL-Cholesterol), CAT, MDA levels and to correlate CAT/PON1 ratio with Glycosylated Hemoglobin (HbA1c) levels.

Keywords

Diabetes Mellitus, Paraoxonase, Oxidative stress, CAT/PON1 ratio