International Journal of Clinical Biochemistry and Research
  • Year: 2016
  • Volume: 3
  • Issue: 1

Serum ferritin level in type 2 diabetes mellitus -A case control study

  • Author:
  • Sangappa Virupaxappa Kashinakunti1,, Kavitha Hiremath2, Manjula Rangappa3, Gurupadappa Shantappa Kallaganada4
  • Total Page Count: 5
  • Page Number: 62 to 66

1Professor, Department of Biochemistry, S. Nijalingappa Medical College, Navanagar, Bagalkot-587102, Karnataka, India

2Assistant Professor, Department of Biochemistry, S. Nijalingappa Medical College, Navanagar, Bagalkot-587102, Karnataka, India

3Associate Professor, Department of Community Medicine, S. Nijalingappa Medical College, Navanagar, Bagalkot-587102, Karnataka, India

4Professor and HOD, Department of Biochemistry, Shimoga Institute of Medical Sciences, Shimoga-577201, Karnataka, India

*Corresponding Author: E-mail: drsvkashinakunti@yahoo.co.in

Online published on 22 June, 2016.

Abstract

Hyperferritinemia probably contributes insulin resistance and subsequently to decreased insulin secretion causes for development of insulin resistance.

Compare HbA1c with Ferritin and find correlation between HbA1c and ferritin in type 2 diabetes mellitus patients, and also to find the best cut-off value for serum ferritin.

The study was conducted on type 2 diabetes mellitus patients attended the outpatient department. Totally 99 participants were enrolled for the study, out of which 49 were cases and 50 were age and sex controls. The FBS, PPBS, HbA1c and serum ferritin were estimated. Statistical package for social science software version 19.0 was used for statistical analysis.

There statistically significant increase in all the biochemical parameters viz FBS, PPBS, HbA1c and serum ferritin levels in cases compared controls. The p value was 0.0001 for all the parameters, which is highly significant. There was a positive correlation between the HbA1c and Ferritin levels, but it was not statistically significant (r = 0.10). The area under the ROC curve for serum ferritin values at various cut-off was 0.904 and the best cut-off of serum ferritin levels greater than 124ng/ml.

Serum ferritin levels were higher in type 2 Diabetes mellitus which positively correlated HbA1c. Thus, routine screening for serum ferritin concentration in diabetes patients can be done to assess the glecemic control in type 2 DM.

Keywords

Type 2 Diabetes Mellitus, Serum ferritin