1Assistant Professor, Dept. of Bio-Chemistry, Sri Guru Ram Das Institute of Medical Science & Research, Amritsar
2Professor & Head, Dept. of Bio-Chemistry, Sri Guru Ram Das Institute of Medical Science & Research, Amritsar
3Major, Army Medical Corps
4Intern, Dept. of Bio-Chemistry, Sri Guru Ram Das Institute of Medical Science & Research, Amritsar
*Corresponding Author: Email: amandeepbest@gmail.com
Online published on 15 September, 2016.
Type 2 diabetes mellitus is a worldwide endemic disease. Dyslipidemia is also a frequent disorder associated with diabetic patients. The present study is an attempt to link that elevated levels of adenosine deaminase in Type 2 diabetes mellitus patients augment hyperlipidemia.
The subjects included in this study were divided into 3 groups. Group A consisted of 30 normal healthy individuals who served as controls with no history of DM. Group B consisted of 30 patients of Type 2 Diabetes Mellitus both males & females in the age group of 40–65 years on oral hypoglycaemic drugs with HbA1c <7%. Group C consisted of 30 patients of Type 2 Diabetes Mellitus both males & females in the age group of 40–65 years on oral hypoglycaemic drugs with HbA1c >7%. Serum levels of fasting blood sugar, HbA1c, ADA and lipid profile were estimated in all the subjects under study.
All the three parameters, FBS, HbA1c and ADA levels were found to be increased in the patients of Type 2 DM as compared to controls. The mean S. Triglyceride and S. VLDL-C levels were significantly elevated in group C as compared to Group A. The mean serum levels of S. HDL-C showed a decreasing trend with increase in levels of HbA1c.
From the present study, it was concluded that dyslipidemia was found to be higher in diabetic patients with respect to healthy controls. The lipid abnormality (dyslipidemia) associated with type 2 diabetes typically consists of elevated triglyceride and decreased HDL-C levels.
Diabetes Mellitus type 2, Adenosine deaminase (ADA), Glycated haemoglobin (HbA1c), Fasting blood Sugar (FBS)
