To study an alteration in biochemical parameters in acute and chronic phase of respiratory acidosis and alkalosis

The primary abnormality in respiratory acidosis is retention of CO₂ (increased H₂CO₃) due to impaired alveolar ventilation resulting in a rise in pCO₂ causing acidemia. However, respiratory alkalosis occurs when there is decrease in H₂CO₃ concentration. A fall in pCO₂, reduces the ratio of carbonic acid to bicarbonate resulting in alkalemia.

To study variations in biochemical parameters in respect to respiratory acidosis and alkalosis.

The biochemical parameters of respiratory acidosis and alkalosis like blood pH, concentration of CO₂, pO₂, pCO₂, level of HCO₃⁻.

The studied components of respiratory acidosis and alkalosis were found to be highly significant in chronic conditions of respiratory acidosis and alkalosis (p<0.01) than acute condition of respiratory failure when compared with the healthy controls.

In this study, we observed that there is marked increase in product of metabolism in acute and chronic phase of respiratory syndrome when compared with the healthy controls.