Role of biomarker of Oxidative stress in preeclampsia

To evaluate the role of biomarker of oxidative stress in predilection of pregnancy induced hypertension.

A sample of 200 pregnant women was examined at department of Gynecology and obstetrics at tertiary care hospital from the period of July 2008 to march 2010. Pregnant women were divided into three groups including 100 normal healthy pregnant women which were controls. Another 100 pregnant women having increased blood pressure and proteinuria divided into two groups depend on severity on B.P. and urinary proteinuria. Groups were compared for the levels of antioxidant biomarker for the statistical analysis, suitable test for these qualitative variables with 5% significance were used.

Preeclampsia remains a frequent and potentially dangerous complication of pregnancy. The cause remains largely unknown, but oxidative stress and a generalized inflammatory state common are features. In present study, patient with pregnancy induced hypertension shows MDA levels were found significantly higher, while Vitamin C and Vitamin E levels are significantly lower compared with normal healthy pregnant women.

A combination of vitamins C and E administration can be found promising for prevention of preeclampsia. As small study group, our study has a limited statistical power if significance several multicenter randomized clinical trials are further required.