Correlation of Serum C-peptide and Serum uric acid Levels with Glycated Hemoglobin in Patients of Type 2 Diabetes Mellitus

Alterations in serum uric acid levels are associated with changes in Blood glucose. While impaired Glucose tolerance is accompanied with increased levels of Uric acid, the levels decrease once overt diabetes develops. This necessitates the screening of Type 2 Diabetes Mellitus to prevent the development of hyperuricemia and gout.

It was a Cross-sectional observational study. The subjects included in the study were divided into two groups.

composed of 50 normal healthy individuals, in the age group of 40–65 years of either sex with no family history of diabetes mellitus.

comprised of 50 newly diagnosed patients of Type 2 Diabetes Mellitus in the age group of 40–65 years of either sex from the same population. Fasting blood sample was withdrawn and investigated for serum c-peptide, serum uric acid, fasting blood sugar and HbA1c.

The values of the patients were compared with that of normal healthy subjects. The parameters, serum c-peptide and serum uric acid were found to be significantly increased in the patients of Type 2 Diabetes Mellitus as compared to controls (p<0.001). Uric acid showed a positive correlation with serum c-peptides (r=0.224).

The rising incidence of Type 2 Diabetes Mellitus (T2DM) indicates the importance of screening and thus Blood Glucose, C-peptides and HBA1c should be evaluated in all subjects over 40 years of age as recommended by American Diabetic Association. This should be accompanied by measurement of Serum uric acid levels as they rise in the early stages of the disease to prevent gout. This should be further monitored with the progression of disease and treatment as uric acid shows a bell shaped changes.