1Assistant Professor, KS Hedge Medical Academy, Mangalore
2PG Student, KS Hedge Medical Academy, Mangalore
3Tutor, Dept. of Biochemistry, Mysore Medical College & Research Institute, Mysore
Type 2 diabetes mellitus and its complications is an important health problem.
As oxidative stress and inflammation appears to play a major role in the pathogenesis of diabetes mellitus and development of its complications; we intend to study the serum GGT activity and hs-CRP levels in type 2 diabetes mellitus without complications, type 2diabetes with complications and age and sex matched normal controls.
Study consisted of 75 subjects out of whom 25 subjects were type 2 diabetics without any complications, 25 subjects were type 2 diabetics with complications and 25 were age and sex matched normal controls. Serum GGT, serum hsCRP, FBS and glycated hemoglobin were measured in these subjects.
Levels of serum hs-CRP and GGT is increased in type 2 diabetics without any complications and type 2 diabetics with complications, when compared to controls, which was statistically significant (p < 0.001).
Present study showed increase in the levels of hs-CRP and GGT levels in type 2 diabetics without complications and type 2 diabetics with complications when compared to healthy controls. These findings provide evidence that oxidative stress and inflammation plays a role in the pathogenesis of diabetes mellitus and development of its complications.
Type 2 diabetes mellitus, Oxidative stress, Inflammation, Gamma glutamyl transferase, High sensitive C-reactive protein
