Speculation of diabetic nephropathy by pro-inflammatory cytokines (IL-6, IL-10) & renal biomolecules

Type 2 diabetic nephropathy (T2DN) develops inflammation in kidney which leads to failure. Study designed to evaluate risk of diabetic nephropathy (DN) by inflammatory gene expressions (IL6, IL10) and renal parameters at the early stage in type II diabetes mellitus (T2DM) in Indian population.

This study includes 241 subjects (118 men, 123 women, and age ranges 30–70 years, distributed in three groups on the basis of age. Subjects recruited after screening for T2DM by measurement of blood glucose in fasting, post-prandial and glycosylated hemoglobin, microalbumin was measured from spot urine for screening of DN.

Analysis of data of routinely used renal parameters found within reference interval except e-GFR marginally deviated from control group (p <.00). Other parameters showed marginal significance within and between the groups. Pro-inflammatory cytokines IL-6 and IL-10 evaluated by rt-PCR, showed high degree of significance (p <.00) in both study groups. Results of this study suggest that measurements of renal parameters are not enough to diagnose early stage of diabetic nephropathy (DN) and eventually to prevent progression of the disease.

It was concluded that early measurement of IL6, IL10 along with direct and indirect renal marker was suggested to prevent morbidity & mortality in DN.