Assistant Professor, Dept. of Biochemistry, Govt. Medical College, Miraj, Maharashtra
Alteration of lipid levels in ARF patients fastens the atherosclerotic process which causes cardiovascular complications.(1) It is observed that levels of different lipoprotein fractions were changed in acute renal failure patients.
This case control study includes total 100 subjects. Out of these 50 subjects were clinically diagnosed ARF patients having age more than 20 years and remaining 50 subjects were chosen from healthy controls not having any major medical problem. Fasting venous blood samples were collected and serum levels of Total cholesterol (TC), Triglycerides (TG), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C), Very low density lipoprotein cholesterol (VLDL-C) were measured.
It is seen that Total cholesterol, Triglycerides, Very low density lipoprotein cholesterol and Total cholesterol to High density lipoprotein cholesterol ratio were significantly increased in ARF group as compared controls while mean value of High density lipoprotein cholesterol was significantly decreased in ARF as compared to control. The mean level of Low density lipoprotein cholesterol did not show any significant difference between these two groups i.e. controls & ARF.
The present study indicates that due to dyslipidemia in ARF, there is increased risk of cardiovascular complications.
ARF, Lipid profile, Total cholesterol, HDL-C
