Status of Pro-Inflammatory Marker IL-6 and Microalbuminuria in type-2 Diabetic Nephropathy subjects

Diabetic nephropathy is a progressive renal complication of type-2 diabetes. Inflammation is found as main cause of diabetic nephropathy pathogenesis. Cytokines influence inflammatory and immune responses by their effects on cells. Chronic low-grade inflammation together with innate immune system activation is closely associated in diabetes mellitus pathogenesis and its micro-vascular complications.

The aim of this study is to estimate the level of pro-inflammatory marker IL-6 and microalbuminuria in subjects diabetic nephropathy compared to non-diabetic healthy subjects.

The study was conducted at Government Medical College, Banda as well as M.L.N. Medical College, Allahabad (UP). The study was made on a group of 150 selected subjects. From these, 50 were healthy subjects without Diabetes and100 were patients of diabetic nephropathy of type-2 DM. They were evaluated by measurement of various parameters such as BP, blood parameters as FBS, HbA1c, lipid profile level, serum urea, serum creatinine, Serum albumin, A: G ratio and inflammatory marker like IL-6.

Elevated Blood Pressure and serum levels of FBS, Hb A1c, serum urea, serum creatinine, TC, TG, LDL, VLDL, IL-6 level and reduction in HDL, Serum albumin, A/G ratio were observed in diabetic nephropathy subjects. These values of biochemical markers were found to be significant statically.

An increase in the levels of inflammatory marker like IL-6 in DN patients with contrast to normal levels of these parameters shows a significant role in development of DN.