The synergistic role of CKMB mass and high sensitivity Troponin T in the diagnosis of Acute Coronary Syndrome

To determine the synergistic role of CKMB mass (CKMBM) and high sensitivity Troponin T (hs-cTnT) in the diagnosis of Acute Coronary Syndrome (ACS).

This was a cross-sectional study comprising of 140 individuals out of which 90 were cases and 50 healthy controls. The study was carried out in a tertiary care hospital between July 2014 to June 2015.

On the basis of clinical history and 12 lead electrocardiogram initial diagnosis of acute coronary syndrome was made in the cases. High sensitivity troponin T and CKMB mass was measured in all the individuals.

The sensitivity, specificity, positive and negative predictive value is 80.3%, 86.2%, 92.4% and 67.5% in case of CKMBM, while it is 98.3%, 65.5%, 85.7% and 95% in case of hs-cTnT, while the area under curve in case of CKMBM is 0.832 and in case of hs-cTnT is 0.819.

Thus, we have concluded that hs-cTnT and CKMBM correlate well in the diagnosis of ACS. But hs-cTnT can detect false positive cases which can be avoided by using CKMBM along with hs-cTnT in the diagnosis of ACS.