Association between type 2 diabetes mellitus and hypovitaminosis D

Vitamin D is an important component in regulating the biological functions of the body in various ways. Many studies repeatedly explained the role of vitamin D in the pathogenesis and treatment of various diseases. Recent studies proved a correlation between vitamin D deficiency and prevalence of Type 2 Diabetes and its complications.

to find out the possible correlation between Vitamin D and T2DM. Mainly in this study we have tried to correlate serum 25(OH) D levels with HbA1c levels.

The present study was carried out in the Department of Biochemistry on 120 subjects patient in the age group of 35–70 years, attended OP in Hind Institute of Medical Sciences. Among them 60 healthy subjects enrolled as control group remaining 60 T2DM patients were served as case group. Serum 25hydroxyvitamin D levels were estimated by chemiluminescence immunoassay (CLIA), glycosylated hemoglobin (HbA1c) was measured by IFCC method by using ALERA AFINION AS 100.

The concentration of serum 25-OH vitamin D levels were significantly (p<0.0001) lower in cases (22.92±6.66) as compared to the controls (35.96± 8.46). There was negative correlation found between 25-OH vitamin D levels and glycosylated hemoglobin (HbA1c) in cases of type 2 DM.

Prevalence of hypovitaminosis D was appeared to be more common T2DM patients in compare to non diabetic healthy population. There is a negative correlation exists between serum 25 hydroxy vitamin D and HbA1C (glycemic Control).