Gamma Glutamyl Transferase in Impaired Glucose tolerance and type 2 Diabetes Mellitus

The current study was undertaken, 1. to compare serum levels gamma glutamy transferase in among three groups namely type II diabetes mellitus, impaired glucose tolerance and apparently healthy controls; 2. to measure the association of gamma glutamy transferase levels and the risk of type II diabetes mellitus by logistic regression and to detect the best cut-off value for gamma glutamy transferase in type II diabetes mellitus and impaired glucose tolerance by ROC curve.

The study was conducted at tertiary care hospital, Bagalkot, Karnataka, India. Under aseptic precautions 5 ml of fasting venous sample was collected and biochemical parameters FBS, PPBS, HbA1c, lipid profile, liver enzymes, serum gamma glutamy transferase were estimated. SPSS for window version; SPSS, 11.5 Inc, Chicago IL was used for statistical analysis.

Only gamma glutamy transferase and BMI could fit in the model, whereas raised gamma glutamy transferase was associated with type II diabetes mellitus with odds ratio of 1.37 (P<0.001), whereas in the presence of raised BMI, odds ratio was 1.44(P<0.008). Even in impaired glucose tolerance, raised gamma glutamy transferase was associated with OR of 1.55 (p<0.001). The best cut-off value for gamma glutamy transferase was 24.3 mg/dL, in both type II diabetes mellitus and impaired glucose tolerance.

An increase in gamma glutamy transferase concentration within its physiological range is a sensitive and early biomarker for the development of impaired glucose tolerance and type II diabetes mellitus, with best cut-off value of 24.3 mg/dL.