1Assistant Professor, BKL Walawalkar Rural Medical College, Maharashtra,
2Associate Professor, Dept. of Biochemistry, Govt. Medical College, Akola, Maharashtra,
3Associate Professor, Dept. of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Maharashtra, India
*Corresponding Author: Email id: jayshrijankar@gmail.com
Online published on 2 January, 2019.
Nitric oxide (NO) is known as a mediator in a broad cluster of biological systems. NO is the endothelium-derived relaxing factor, which causes vasodilation by relaxing vascular smooth muscle. This role of NO plays an important role of diabetic nephropathy in Type 2 Diabetes Mellitus (DM)
To assess serum nitric oxide levels among type 2 diabetes mellitus patients having normoalbuminuria and microalbuminuria
This cross sectional study was carried out at Department of Biochemistry in a tertiary care rural hospital in Central India with 200 diagnosed patients of type 2 diabetes mellitus
24 hr urine albumin was done in all the patients. Based on the concentration of albumin in urine, patients were categorised in two groups, group 1 had normoalbuminuria (i.e. Urine Albumin <20 mg/24 hr) and group 2 had microalbuminuria (i.e. Urine Albumin >20 to <300 mg/24 hr). Then, serum NO was assessed and compared in these groups
Serum NO levels were significantly raised (p <0.05) in Group 2 as compared to Group 1
Our observations suggest that serum NO levels measurement has a good detection potential for early stages of diabetic nephropathy manifested in the form of microalbuminuria in Type 2 DM
Diabetic Nephropathy, Microalbuminuria, Nitric Oxide, Normoalbuminuria
