1Assistant Professor, Dept. of Biochemistry, East Point College of Medical Sciences, Bengaluru, Karnataka
2Assistant Professor, Dept. of Biochemistry, G.M.E.R.S. Medical College, Patan, Gujarat
3Assistant Professor, Dept. of Biochemistry, East Point College of Medical Sciences, Bengaluru, Karnataka
4Professor, Dept. of Cardiology, Nizam's Institute Of Medical Sciences, Hyderabad, Andhra Pradesh
5Consultant Biochemist and Head of Laboratory Medicine, Care Hospitals, Hyderabad, Andhra Pradesh, India
*Corresponding Author: Email: shylajavishal@gmail.com
Online published on 2 January, 2019.
Detecting AKI in a timely fashion with the current AKIN staging criteria is a challenge because the diagnosis of AKI is usually based on changes in serum creatinine (SCr) which is a poor marker of early renal dysfunction
To study the role of Serum Neutrophil Gelatinase-Associated Lipocalcin (NGAL) as early biomarker for the detection of Contrast induced acute kidney injury (CIAKI) in subjects undergoing Percutaneous transluminal coronary angiogram (PTCA) with normal eGFR
Prospective cohort study was conducted, where SCr and serum NGAL were serially measured in a heterogeneous group of subjects (n=60) presenting to cardiology department
The study population consisted of 60 subjects. All subjects were divided into 2 groups “CIAKI group” and “no-CIAKI group” according to predefined definition. The serum NGAL increased and reached its peak at 4 hours after contrast media (CM) administration and did not returned to baseline by 24 hours while the SCr increased at 24 hours and reached peak at 48 hours respectively (P<0.001). Thus, 4 hours after CM administration were considered to be appropriate time point for NGAL measurement and there was no significant correlation between serum NGAL with SCr at 0 hours, 4hours, 24 hours and 48hours
In our study, we found that serum NGAL promises to be a simple, safe, non-invasive and reliable early biomarker for predicting possible onset of CIAKI following contrast administration.
Contrast induced acute kidney injury, Percutaneous Trans luminal Coronary angiogram, Serum Creatinine, Estimated glomerular filtration rate
