Indian Journal of Contemporary Dentistry

“Every medication can produce untoward consequences even when used appropriately. Adverse drug reactions can involve any organ and system of the body including the mouth and are frequently mistaken for signs of underlying disease”. An adverse drug reaction (ADR) is defined by the WHO as a drug response that is noxious and unintended and occurs at doses normally used in humans for prophylaxis, diagnosis or therapy of a disease or for the restoration, correction or modification of a physiological function. All noxious and unintended responses to a medicinal product related to any dose should be considered adverse drug reactions. Systemic or local drug therapy has been found to affect teeth in numerous ways. These adverse effects may manifest in numerous ways viz tooth discoloration, physical damage to the tooth structure, alteration in tooth sensitivity.