1Reader, Dept of Oral Pathology & Microbiology, Rajasthan Dental College & Hospital, Jaipur
2Reader, Dept of Oral & Maxillofacial Surgery, Jodhpur Dental College & Hospital, Jodhpur
3Post Graduate Student, Dept of Oral Pathology & Microbiology, Rajasthan Dental College & Hospital, Jaipur
*Corresponding author: Dr. Pooja Narain (Reader), Address S-29/A, Krishna Marg, Shyam Nagar, Sodala, Jaipur - 302019, Rajasthan, INDIA, E mail: drpooja17@yahoo.com Mob: 09314539772
Online published on 15 July, 2015.
To analyze the bcl-2 protein expression in ameloblastoma, the epithelial lining of the Odontogenic keratocyst (OKC), and Dentigerous cysts (DC).
Sixty archival samples of paraffin-embedded tissue sections were utilized. 20 ameloblastoma, 20 OKCs and 20 DC were immunohistochemically analyzed for immunoreactivity of the bcl-2 protein.
Expression of bcl-2 was seen in the peripheral cells and intermediate cells of ameloblastoma, basal layer of the epithelial lining of the OKC. DC showed almost complete negativity for bcl-2. There was a statistically significant increased expression in all ameloblastoma & OKCs.
Keratocystic odontogenic tumour has an equally aggressive potential like Ameloblastoma since the intensity of Bcl -2 expression was the same in both. Our results assert that OKC can be of neoplastic rather than a cystic nature thus justifying the WHO classification of OKC as ‘Keratocystic Odontogenic Tumour’.
Bcl-2, immunohistochemistry, ameloblastoma, odontogenic cysts
