1Post Graduate Student, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh
2Prof. & Head, Dept. of Oral Pathology & Microbiology, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh
3Post Graduate Student, Dept. of Oral & maxillofacial Surgery, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh
4Reader, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh
5Senior Lecturer, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh
6Reader, Dept. of Oral Medicine & Radiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh
Fibrous dysplasia is a common benign skeletal lesion that may involve one bone (monostotic) or multiple bones (polyostotic) and occurs throughout the skeleton with a predilection for the long bones, ribs, and craniofacial bones. The etiology of Fibrous dysplasia has been linked to the posygotic mutation in the GNAS 1 (guanine nucleotide-binding protein, alpha stimulating activity polypeptide 1) gene (20ql3.2–13.3) resulting in up-regulation of cAMP. It may be isolated to a single skeletal site or multiple sites and sometimes is associated with extraskeletal manifestations in the skin and/or endocrine organs (McCune-Albright syndrome).
Fibrous Dysplasia, Monostotic, Polyostotic, GNAS1, cAMP
