Department of Microbiology, Saraswathi Institute of Medical Sciences, Hapur, (UP), India
*Corresponding author: Sanjeev Dimri, Associate Professor, Department of Microbiology, Saraswathi Institute of Medical Sciences, Hapur, (UP), India, Tel: +919958322747, Email: sdimri1966@yahoo.co.in
Online published on 7 October, 2013.
The aim of this study was to determine inducible clindamycin resistance in erythromycin resistant, clindamycin-sensitive staphylococcal strains isolated from clinical specimens.
A total of 108 erythromycin-resistant, clindamycin-sensitive staphylococcal isolates from various clinical specimens were tested using D-test according to CLSI guidelines.
A total of 23 (21.3%) staphylococcal isolates were found to be D-test positive and demonstrated inducible clindamycin resistance (iMLSB phenotype). MRSA isolates showed highest percentage (25.8%) of inducible clindamycin resistant phenotypes.
Inducible clindamycin resistance should be checked in staphylococcal isolates before administering clindamycin therapy in staphylococcal infections as it can lead to clinical failure.
D-test, MRSA, iMLSB Phenotype, Clindamycin, erm Methylase
