1Associate Professor, Department of Pathology, Mayo institute of medical sciences, Gadia, Barabanki, Lucknow, Uttar Pradesh, India
2Associate Professor, Department of Medicine, School of Medical Science and Research, Greater Noida, Uttar Pradesh, India
3Professor and HOD, Department of Pathology, Dr. B. R. Sur Homeopathic Medical College and Hospital and Research center, New Delhi
4Professor, Department of Pathology, School of Medical Science and Research, Greater Noida, Uttar Pradesh, India
5Professor, Department of Pathology, Santosh Medical College, Ghaziabad, Uttar Pradesh, India
Online published on 7 October, 2013.
Bone marrow is a reservoir of stem cells and is the site of origin of numerous primary hematological malignancies and is commonly infiltrated by malignant cells in non-hematological malignancies in advanced stages.
The present study (2002 - 2012) has been aimed to report our experience with one hundred eighty five (185) patients from North India. A comparative study of bone marrow aspiration (BMA) and bone marrow biopsy (BMB) was done simultaneously, where the clinical history was correlated before and after chemotherapy and radiotherapy.
In our study we have included cases of malignant disorders (hematological malignancies and non-hematological malignancies). In each case bone marrow aspiration and biopsy were done before and after chemotherapy and radiotherapy. Aspirate particles, smears, touch imprints of the biopsy core and paraffin sections of the biopsy core were routinely examined.
In our study we have included cases of hematological malignancies (Leukemia, Multiple Myeloma and Malignant Lymphoma) and non-hematological malignancies (Carcinoma of Breast, Prostate, Lung, Kidney, Urinary bladder, GIT, Thyroid, Round cell tumors and Indeterminate tumors). In hematological malignancies, non-Hodgkin's lymphomas (NHL) were maximum thirty cases (28.03%) and hairy cell leukemia (HCL) one case (0.93%). In non-hematological malignancies or primary tumors, there were maximum cases of breast carcinoma, twenty four cases (30.76%) and minimum two cases of thyroid carcinoma (02.56%).
Malignant disorders were more prevalent in males and were seen in all the age groups. In this study bone marrow aspiration was found adequate in hematological malignancies especially in leukemia. Bone marrow biopsy found to be more informative in lymphoma and Metastatic tumors Bone marrow involvement indicated poor prognosis in metastatic tumors except in seven cases (18.42%) of malignant lymphoma. There was no complication of the procedure even in cases of thrombocytopenia.
Bone Marrow, Hematological Malignancies, Non-Hematological Malignancies
