Oxidant and Antioxidant Status in CRF

Oxidative stress plays a significant role in pathogenesis of chronic renal failure (CRF). Redox imbalance caused by increased ROS production and/or reduced antioxidant reserve, leading to pathological consequences including damage to proteins, lipids and DNA. The present paper focuses on the extent of free radical damage on lipid (measured as malondialdehyde, MDA) and effect on antioxidant defense mechanism (measured as vitamin C) in the serum of CRF patients predialytically.40 cases and 40 controls between age group of 25 - 60 were taken. The level of MDA, creatinine, blood urea nitrogen was significantly increased, antioxidant vitamin levels were decreased in CRF patients as compared to normal subjects. The elevated MDA level can lead to lipid peroxidation and can also promote the complication of CRF. The antioxidant levels were decreased, so these patients can be supplemented with antioxidant vitamins for preventing lipid peroxidation and occurance of complication.