International Journal of Contemporary Medicine
  • Year: 2014
  • Volume: 2
  • Issue: 2

Association of Acanthosis Nigricans with Diabetes Mellitus and Family History of Diabetes in 1° Relatives of PCOS Women in South Indian Population

1Assistant Professor, Dept. of Biochemistry, ICARE, Institute of Medical Sciences & Research, & Dr. B. C. Roy Hospital, Haldia, West Bengal

2Asst. Prof., Biochemistry, IQ City Medical College, Durgapur, West Bengal

3Asst. Prof, Community Medicine, IQ City Medical College, Durgapur, West Bengal

4Research Scholar, Presidency College, University of Kolkata

Online published on 31 January, 2015.

Abstract

To determine the association of acanthosis nigricans; as a predictor of diabetes mellitus and hormonal disturbance in patients with PCOS.

Prospective study

Kasturba Medical College Hospital

Fifty one females with PCOS diagnosed by Rotterdam criteria were enrolled. Methods: Patient with PCOS were examined in detail for anthropometry, blood pressure, hirsutism and acanthosis nigricans and other markers insulin resistance. Biochemical estimation such as fasting glucose and fasting lipid profile with a oral GTT were done. Analysis of TSH, FSH, LH, DHEA-S, Testosterone, cortisol were done by radioimmunoassay.

Fifty one females with PCOS were enrolled for the study of which (87%) 44 were having acanthosis nigricans and among those (81%) 36 had diabetes. P<0.001, which is statistically very high significant

Acanthosis nigricans could emerge as a marker of diabetes mellitus in PCOS subjects in South Indian population.

Keywords

PCOS, Diabetes, Acanthosis Nigricans