International Journal of Contemporary Medicine
  • Year: 2015
  • Volume: 3
  • Issue: 1

Study of Serum Tumor Necrosis Factor Alpha (TNF-A) and Interleukin-6 (IL-6) in Male Pulmonary Tuberculosis Patients

1Reseach Scholar, Department of Microbiology, Barkatullah University, Bhopal (M.P.)

2Associate Professor, Department of Biochemistry, U.P. RIMS & R Saifai, Etawah (U.P.)

3Professoer & Head, Department of Microbiology, Barkatullah University, Bhopal (M.P.)

*Corresponding author: Pradeep Sharma, Associate Professor, Department of Biochemistry, U. P. Rural Institute of Medical Science & Research, Saifai, Etawah (U. P.), Mobile No. 9027155457, Email Address: pradeepsharma2001@rediffmail.com

Online published on 31 January, 2015.

Abstract

Pulmonary tuberculosis has been declared a global emergency by the world health organization. TNF-α, IL-6 are central cytokines in the regulatory and effector phases of the immune response to pulmonary tuberculosis. TNF-α, IL-6 are thought to play a part in human cell-mediated immune response to infection with mycobacterium. TNF-α is also required for localization of mycobacterial infection and granuloma formation. IL-6 is multifunctional cytokines regulating immune response and the acute phase protein response in pulmonary tuberculosis The present study is being carried out in 150 male subjects of age group 40–60 years suffering from pulmonary tuberculosis and 50 normal healthy control male subjets of same age group. The TNF-α and IL-6 were measured in the serum by enzyme linked immunosorbent assay technique. TNF-α and IL-6 levels were high as compared to control male subjects (P<0.001).

Keywords

TNF-α, IL-6 and Pulmonary tuberculosis