1Assistant Professor, Deptt. of Physiology, IGIMS, Patna
2Senior Resident, Deptt. of Physiology, IGIMS, Patna
3Professor & H.O.D, Deptt. of Physiology, IGIMS, Patna
4Associate Professor, Deptt. of Physiology, IGIMS, Patna
5Ex-Professor, Deptt. of Medicine, MAMC, Delhi
6Assistant Professor, Deptt. of Biochemistry, IGIMS, Patna
7Professor, Deptt. of Biochemistry, MAMC, Delhi
Comparison of verbal, visual and working memory in Subclinical Hypothyroid and euthyroid subjects.
Sixty diagnosed cases, all female, with mean age of 67.43 ± 6.82 years of subclinical hypothyroidism (SCH) were compared with 60 age and sex matched euthyroid controls. Neurocognitive tests such as Mini Mental State Examination (MMSE), Rey's Auditory Verbal Learning Test (RAVLT), Rey's complex figure test (CFT) and Wechsler Memory Scale (WMS) -digit and spatial span were performed in both the groups and were compared. Results were analyzed by calculating Mean±SD, using Student's t test.
The characteristics of SCH patients and control cases were similar with regard to age, sex, and body mass index (BMI). Serum thyroid stimulating hormone levels (TSH) were significantly higher in SCH patients than the controls (P < 0.001). Euthyroid control (Group 2) had performed better on following test for memory; RAVLT: Total, Average, immediate recall and delayed recall scores; CFT: 3 minutes and 30 minutes; WMS-spatial span-forward and backward when compared to SCH subjects (Group 1). No statistically significant difference was found in the score of Mini Mental State Examination (MMSE), although the score was lower in SCH patient.
Our study shows decline in verbal, visual and working memory in SCH subjects compared to Euthyroid control.
Memory, Subclinical Hypothyroidism
