1Resident Dept Respiratory Medicine, Subharti Medical College, Swami Vivekanand Subharti University, Meerut (U.P.)
2Professor and Head, Dept. of Respiratory Medicine, Subharti Medical College, Swami Vivekanand Subharti University, Meerut (U.P.)
3Prof, Dept. of General Medicine, Subharti Medical College, Swami Vivekanand Subharti University, Meerut (U.P.)
4Asst Prof, Dept of Respiratory Medicine, Subharti Medical College, Swami Vivekanand Subharti University, Meerut (U.P.)
5Resident, Dept of Respiratory Medicine, Subharti Medical College, Swami Vivekanand Subharti University, Meerut (U.P.)
In recent years Vitamin D has been shown to be effective in prevention and treatment of tuberculosis. Active primary metabolite of Vitamin D is 1,25(OH)2D which is a steroid hormone which acts as a metabolite for several Vitamin D receptors (VDR) including cell membrane receptors (mVDR) and nuclear receptor (nVDR) activating several transcription factor complex.(7,8,9)
To access the effectiveness of supplementation of vit-D in tubercular patients the study was undertaken. A total of 100 patients were enrolled of which 50 were cases and 50 were controls. The patients presenting with symptoms suggestive of pulmonary Tuberculosis like Fever, Chronic cough > 2 weeks, weight loss with decrease appetite, night sweats were selected in both study and control groups. The patients in the study group were supplemented with vitamin- D along with ATT for six month and control group with only ATT.
The result suggested the synergistic role of vitamin D along with ATT led to improvement in clinical and bacteriological status of patients.
Vitamin D (vit.-d), Tuberculosis, Acid Fast Bacilli, Zeihl-Neelsen staining
