1Assistant Professor, Department of Medicine, F.H. Medical College, Tundala, Uttar Pradesh
2Professor, Department of Medicine, SMS &R, Gr. Noida, Uttar Pradesh
3Assistant Professor, Department of Pathology, SMS &R, Gr. Noida, Uttar Pradesh
4Professor, Department of Pathology, SMS &R, Gr. Noida, Uttar Pradesh
Opportunistic infections (OI) account for the majority of deaths in untreated patients with AIDS. The actual frequency of infections varies in different parts of our country.
To detect the presence of different OI and hematolymphoid neoplasms in HIV patients of two tertiary care centers near Delhi by clinical examination and on trephine biopsy.
This study was conducted on 50 HIV positive cases that were enrolled after ELISA testing for HIV antibody. Thorough clinical examination was carried out in all cases. Bone marrow aspirates were taken in all the patients. Bone marrow biopsies were performed in 20 of these cases as per the clinical indication (18 cases from PSIS and 2 cases from the sternum). The special stains Ziehl Neelsen stain, Gram's stain as per the clinical indication.
The OI found on trephine biopsy were tuberculosis (6 cases) followed by one case of Leishmaniasis and another case of Plasmodium falciparum.
There was one case of acute myeloid leukemia and another one case of NHL.
Bone marrow examination is indicated as per clinical requirement; but whenever indicated trephine biopsy should always be included. The opportunistic infections and neoplastic complications can be detected by thorough examination of bone marrow aspirate and biopsies. The biopsy may show granulomas or lymphomatous infiltration when the aspirate is uninformative. These can be treated adequately and appropriate prophylaxis should be administered for the prevention of recurrence of opportunistic infections.
HIV (Human immune deficiency virus), opportunistic infections, CD4+count
