Study of Drug-Dosage in Tuberculosis of Childhood in Rajasthan Population

In the present study, out of 80 tuberculosis children 50% were malnutritious, 25% were MDRTB, 25% were HIV infected tuberculosis. Peak concentration of anti-TB drugs of children of different ages. INH peak concentration was3.4μg/ml, in 1–3 years of age, 6.7μg/ml in 4-6years, 6.9μg/mi in 6–9 years 7.4μg/ml in 9–12 years of age. Rifampicin peak concentration was 3.2μg/ml in 1–3 years of age, 4μg/ml in 4–6 years, 7.2 μg/ml in 6–9 years.5.8μg/ml in 9–12 years of age. Pyrazinamide peak concentration was 32.1μg/ml in 1–3 years, 39.1μg/ml in 4–6 year, 41.2μg/ml in 6–9 years, 39.1 μg/ml in 9–12 years In daily dosage INH 5mg/kg body weight. Rifampicin 10/kg, PZA 25mg/kg. Ethambutol 15mg/kg and intermittent dosage (three times weekly) INH 10mg/kg, Rifampicin 10mg/kg. PZA 35mg/kg. This study is more or less in agreement with previous studies. The duration of treatment in pulmonary and extra pulmonary and hilar adinopathy the Rifampicin and INH is given for 6 months. In tuberculosis meningitis, bone and joint TB Rifampicin, INH, PZA for 2 months then Rifampicin and INH for 4 months. This study will be certainly help the pharmacist and pediatrician to treat the childhood tuberculosis efficiently because drug concentrations influences by several factors such as age, ethnicity, or genetic factors, nutritional status, human immune deficiency virus (HIV).hence incidence of Tuberculosis increasing worldwide.1 billion people will be newly affected with tuberculosis, 200 million people will develop the disease and 35 million will die from tuberculosis.⁽¹⁾ The profound influence on incidence of tuberculosis is HIV infection, particularly in illiterates and Slum dwellers.