To Study the Role of Metadoxine on Liver Function Tests in the Management of Chronic Hepatitis B Infection

Hepatitis B causes both acute and chronic liver damage where a greater proportion of patients with chronic disease end up with liver cirrhosis and hepatocellular carcinoma (HCC). Despite advances in modern medicine, there is no effective drug available that stimulates liver function, protects the liver from damage or helps to regenerate hepatic cells. Hence, there is a need for safe and effective remedy. The present study was planned to evaluate the role of metadoxine in treatment of patients with chronic hepatitis B (CHB) infection. A total of 40 male and female patients aged between 30–65 years with positive hepatitis B surface antigen were included in the study for six month and informed consent was taken. Patients were treated with 1500mg/day of metadoxine for six months. Liver function tests including total bilirubin, aspartate and alanine transaminase, serum albumin and alkaline phosphatase were done at baseline and repeated at the end of 24 weeks. Statical analysis was carried using Graphpad Prism, version 4.03 for windows, graphpad software. No significant evidence of improvement of biochemical parameters was observed at the conclusion of study.