1Assistant Professor, Department of Medicine, Malabar Medical College, Modakkallur, Atholi, Kozhikode
2Assistant Professor, Department of Medicine, Government T D Medical College, Alappuzha
*Correspondence author: Dr Midhun M Assistant Professor, Department of Medicine, Malabar Medical College Hospital, Modakkallur, Atholi, Kozhikode
Online published on 15 February, 2017.
Different electrolyte disorders in association with thyroid dysfunction were observed in the literature. The effect of thyroid hormones on minerals has not been well established and the underlying mechanism is not well understood too.
to assess the alterations in the levels of serum calcium, sodium, potassium and chlorides and to correlate these minerals with TSH in hypothyroidism.
A case control study is taken up on 50 subjects with hypothyroidism and 50 apparently normal healthy subjects. Venous blood sample is collected from all the subjects. Serum TSH, calcium, sodium, potassium and chlorides are estimated in all the subjects.
A significant decrease in serum calcium, sodium and potassium is observed in cases in comparison to controls (p<0.0001). A significant increase in serum chlorides is ob-served in cases (p=0.03) compared to controls. When correlat-ed with TSH, serum calcium, sodium, potassium and chlorides showed negative correlation in subjects with hypothyroidism.
The present study indicates the profound influence of thyroid hormones on serum electrolytes. This study concludes that serum calcium, sodium and potassium levels are decreased whereas serum chloride levels are increased in hypothyroidism in comparison to euthyroid subjects.
Calcium, Hypothyroidism, Potassium, Sodium, Thyroid Stimulating Hormone (TSH)
