1Assistant Professor, Department of Medicine, GMERS Medical Collage, Sola, S.G. Highway, Ahmedabad, Gujarat, India
2Assoicate Professor, Department of Medicine, GMERS Medical Collage, Sola, S.G. Highway, Ahmedabad, Gujarat, India
*Corresponding Author: Dr. Harsha Jivarajani, Department of Medicine, GMERS Medical Collage, Sola, S.G. Highway, Ahmedabad, Gujarat, India, Tel: 9427350988, E-mail: researchguide86@gmail.com
Online published on 25 January, 2018.
Cirrhosis is a condition that is defined histopathologically as the development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury that leads to portal hypertension and end stage liver disease. Presents study was performed with an aim to study the Clinical and Microbiologic profile of Spontaneous bacterial peritonitis (SBP).
The present cross sectional study was carried out in the department of Medicine, for the period of 2 year. A total of 50 cases of cirrhosis with SBP were studied. The definitive diagnosis of SBP was made if there was a positive ascitic fluid bacterial culture and an elevated ascitic fluid absolute polymorphonuclear leukocyte count of ≥250 cells/mm, in absence of any intra-abdominal source of infection. 10 to 20 ml of fluid was placed in a sterile container for direct microscopic examination, gram-stained film, and culture on routine laboratory media including blood, MacConkey, Mannitol salt agar plates, and thioglycollate broth.
Mean age of study subjects was 46.84 ± 12.4. Most common aetiology for cirrhosis was alcoholism (72%). predominant symptoms in SBP was fever (64%) followed by abdominal pain (16%). Most common organism isolated was E. Coli (44%) followed by Kliebsella (18%), Strep. Viridians 6%), and Enterococcus (6%) and 26% cases had CNNA.
It is imperative to do diagnostic paracentesis for cell count and culture in every cases of cirrhosis with ascites and suggestive symptoms compatible or suggestive of SBP.
Ascites, Cirrhosis, E. Coli, Liver
