1Consultant, Department of Anaesthesia, Mahavir Vatsalya Aspatal, Patna
2Consultant, Department of Anaesthesia, Heritage Hospital, Varanasi
3Assistant Professor, Department of Surgery, IGIMS, Patna
Online published on 16 August, 2018.
Total abdominal hysterectomy is associated with significant blood loss. This study was aimed to evaluate the clinical efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients undergoing hysterectomy.
Forty ASA (American Society of Anesthesiology) class I and II adult female patients, scheduled for total abdominal hysterectomy, were blindly randomized into two groups to receive either intravenous 1 g tranexamic acid 10 min before skin incision or an equivalent volume of normal saline as placebo. All patient's total blood loss was measured and recorded perioperatively at 12 hr postoperatively. The preoperative and postoperative hemoglobin, hematocrit values, serum creatinine, activated thromboplastin time, prothrombin time; thrombocyte count and symptoms thromboembolic events were evaluated.
The tranexamic acid significantly reduced the quantity of total blood loss, 220±52 mL in study group as compared to 410±70 mL in the control group (P<0.01). Postoperatively hematocrit values were higher in the tranexamic acid group. The coagulation profile did not differ between the groups. No complications or adverse effects were reported in the either group.
The prophylactic administration of tranexamic acid had effectively reduced the blood loss and transfusion needs during total abdominal hysterectomy without any adverse effects or complication of thrombosis.
Antifibrinolytic agent, coagulation profile, hematocrit values, tranexamic acid
