International Journal of Contemporary Microbiology

  • Year: 2019
  • Volume: 5
  • Issue: 1

Level of Oxidants and Antioxidants between Premenopausal and Postmenopausal Patients: An Observational and Comparative Study

1Senior Resident, Dept. of Biochemistry, Govt. Medical College, Bettiah

2Specialist Medical Officer, Obstetrics and Gynaecology, Bihar Sharif

3Senior Resident, Dept. of Medicine, Patna Medical College, Patna

4Consultant (DM Gastroenterologist), Curis Hospital, Patna

Online published on 6 April, 2019.

Abstract

This study was conducted to compare the free radical damage in the form of oxidative stress and the antioxidant status in postmenopausal females in comparison to premenopausal females.

200 female subjects (age group 40–50 years) were studied of which 100 were premenopausal and 100 postmenopausal. Oxidative stress was assessed by estimating malondialdehyde (MDA), a lipid peroxidation product in the form of thiobarbituric acid reactive substances. Antioxidants in the form of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), vitamin C and E were measured in both the groups.

On comparative evaluation, SOD, GPx and vitamin C levels were significantly decreased (p <0.001) whereas MDA and CAT levels were significantly increased (p <0.001) in postmenopausal females as compared to premenopausal females. However, there was no significant difference in levels of vitamin E in both the groups (p >0.05).

Risk of oxidative stress in postmenopausal females is greater as compared to premenopausal females and many of the health problems of menopause may be related to increased oxidative damage.

Keywords

Menopause, Free radicals, Lipid peroxidation, Antioxidants