Immunostimulatory potential of Emblica officinalis (Amla) on murine immune system
Abstract
The alcoholic extract of dried Emblica officinalis (Amla) fruit pulp was studied for its effect on cellular and humoral immune functions in mice. The extract was administered once a day orally at two dose levels of 100 mg/kg body weight and 200 mg/kg body weight to mice for 19 days. A significant dose dependent increase in haemagglutination antibody titre, sheep red blood cells induced delayed type of hypersensitivity reaction, macrophage migration index, respiratory burst activity of the peritoneal macrophages, total leukocyte count, percentage lymphocytic distribution, serum globulin and relative lymphoid organ weight were observed in Amla treated mice. The results thus obtained indicated the ability of alcoholic extract of Emblica to stimulate macrophage phagocyte, humoral as well as cell mediated immunity in mice.
