1Scientist, School of Molecular Diagnostics and Prophylactics, ICAR-Indian Instt. of Agril. Biotechnology, Ranchi, Jharkhand
2Assistant Professor, Department of Fisheries Microbiology, College of Fisheries, Mangalore, Karnataka
3Research Professor, Research Institute of Bacterial Resistance, Yonsei Univ. College of Medicine, Seoul, Republic of Korea
4Postdoctoral Fellow, Department of Aqualife Medicine, Chonnam National University, Yeosu, South Korea
5Assistant Professor, Dept. of Aquatic Health and Environment, College of Fisheries, Central Agril. Univ., (Imphal), Tripura
6Senior Scientist, ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Bangalore, Karnataka
*Corresponding author E-mail: vinaytn56@gmail.com
Online published on 21 January, 2017.
The application of new and novel strategies to develop effective vaccines is essential in aquaculture health management. The bacterial biofilm-based oral vaccine development is an innovative technique. Biofilm-based vaccines have very good gastrointestinal stability in comparison with vaccines from conventional free cells (whole bacterial cell) of bacteria. Biofilms are produced by growing bacteria in a nutrient depleted condition providing a substrate for its attachment. The biofilm thus produced, inactivated and delivered orally to various fish species have demonstrated good humoral and protective response than with free cell-based vaccines. The studies have been reported from herbivore carps, omnivore catfish, and carnivore murrel. This review provides the overview of recent advances in bacterial biofilm-based oral vaccinedevelopment for aquaculture species.
Bacterial biofilm, Biofilm vaccine, Oral vaccine, Fish vaccine, Aquaculture
