Microbial profile and antimicrobial sensitivity pattern of isolates from endotracheal specimens of patients in neuro ICU at Suburban India

In ICU or Neuro ICU patients, nosocomial infections are increasingly common due to the frequent use of lifesaving procedures like mechanical ventilation. To diagnose these infections, endotracheal specimens were collected and immediately transported to the laboratory for culture and sensitivity testing. The current study of Neuro ICU patients included a total of 84 samples, of which 64.3% were positive for growth. Different types of isolates were obtained from the collected samples, with Staphylococcus spp. (26.3%) and Pseudomonas spp. (21%) being the most prevalent. The Antibiotic Sensitivity Test (AST) showed that Gram-positive isolates were sensitive to Aminoglycosides, Fosfomycin, Tetracycline, and Chloramphenicol. On the other hand, Gram-negative isolates exhibited sensitivity to tetracycline, Tobramycin, Meropenem, Aminoglycosides, and Fosfomycin. The isolated yeasts were sensitive to Amphotericin-B, Ketoconazole, and Fluconazole. The study also highlighted that 15.7% of the isolated species were multidrug-resistant, posing a major challenge in treating nosocomial infections.