International Journal of Contemporary Pathology
  • Year: 2015
  • Volume: 1
  • Issue: 2

The Pattern Analysis of Immunoreactants in Lichen Planus-an Immuno-histopathological Study

1Asst. Professor, Dept. of Pathology, BLDEU's Shri B.M. Patil Medical College, Vijaypur, Karnataka

2Asst. Professor, Dept. of General Medicine, BLDEU's Shri B.M. Patil Medical College, Vijaypur, Karnataka

3Professor and Head, Dept. of Pathology, BLDEU's Shri B.M. Patil Medical College, Vijaypur, Karnataka

*Corresponding author: Dr. Yashashwini J. Konin Asst. Professor, Dept. of Pathology, BLDEU's Shri B.M. Patil Medical College, Vijaypur, Karnataka. E-mail ID: drshankarpatil68@gmail.com Mobile no: 8123697206.

Online published on 12 October, 2015.

Abstract

Lichen planus is an inflammatory skin disease characterized by faintly erythematous to violaceous, flat topped, polygonal papules with adherent scales. The lesions usually involve flexural areas of the skin, the oral mucous membranes & genitalia. Rare cases of esophageal and ocular involvement are also reported.2Lichen planus frequently occurs between the ages of 30 & 60 years.3 There is no predilection for sex or race.1 The prevalence of the disease is approximately 1% in general population.4

The aim of the present study is to differentiate disease by using Direct Immunoflourescence.

To determine the pattern of immunoreactants in lichen planus by direct immunofluorescence.

Ten patients who were clinically diagnosed as lichen planus were included and the skin biopsies of these patients were studied under H&E and Direct Immunoflourescence.

The most common morphological type was classical lichen planus followed by hypertrophic, generalized and vesicular. The most common immunoreactant was fibrinogen(80%) followed by IgM (50%), C3(50%), Ig G(30%) and Ig A(30%). The present study observed presence of cytoid bodies in 40% of cases.

Keywords

Lichen Planus, Direct Immunoflourescence, Fibrinogen, IgM, IgG, IgA, C3 and Colloid bodies