1Assistant Professor, Department of Pathology, Kakatiya Medical College, Rangampet, Warangal, Telangana, 506007
2Professor, Department of Pathology, Kakatiya Medical College, Rangampet, Warangal, Telangana, 506007
Online published on 13 June, 2016.
Sickle cell disease (SCD) encompasses a group of hemoglobinopathies characterized by a single amino acid substitution in the ß-globin chain. The most frequently occurring form of SCD is sickle cell anemia (HbSS), followed by HbSC and HbSß-thalassemia. The liver can be affected by a number of complications due to the disease itself and its treatment
To analyze the liver function tests in steady state adult SCD patients.
Seventy (n=70) adult SCD patients in steady state and seventy five (n=75) controls were enrolled for this study. Liver function tests was assessed in these subjects
The serum total bilirubin, aspartate transaminase (AST) and alanine transaminase (ALT), alkaline phosphatase (ALP), direct and indirect bilirubin and total protein were significantly increased in SCD patients (P <0.05) compared with controls. Serum iron and ferritin were higher in SCD patients with hepatic disease (p<0.05), which might be due to iron overload. Whereas serum Transferrin and Total Iron Binding Capacity were low in these patients.
The finding of this study state that the biochemical abnormality of liver plays a significant role in sickle cell patient's physiopathology and its management.
Liver function test, sickle cell anemia, serum iron
