International Journal of Contemporary Pathology
  • Year: 2016
  • Volume: 2
  • Issue: 2

Diagnostic Efficacy of Fine Needle Aspiration Cytology in Evaluation of Lymphadenopathy with Histopathological Correlation

  • Author:
  • Ankita Mehta1,, Prathima Shivajirao2, Shivarudrappa Alilaghatta Siddalingappa3, Anil Navale Santhuram4
  • Total Page Count: 5
  • Page Number: 18 to 22

1Post Graduate Resident, Vydehi Institute of Medical Sciences & Research Centre, Whitefield, Bangalore

2Associate Professor, Vydehi Institute of Medical Sciences & Research Centre, Whitefield, Bangalore

3Professor& HOD in, Pathology, Vydehi Institute of Medical Sciences & Research Centre, Whitefield, Bangalore

4Professor & HoD, Department of Community Medicine, ESIC Medical College & PGIMSR, Rajajinagar, Bangalore

*Corresponding author: Dr. Anil Navale Santhuram Professor & HoD, Department of Community Medicine, ESIC Medical College & PGIMSR, Rajajinagar, Bangalore-10, Mobile: +919900165402, Email: anilpsm@gmail.com

Online published on 15 October, 2016.

Abstract

Fine needle aspiration cytology (FNAC) is an integral part of diagnosis in patients with lymphadenopathy due to its simplicity and minimal complications. The aim of this study is to evaluate the efficacy and reliability of FNAC in evaluation of lymphadenopathy and to correlate it with histopathological results.

One year prospective study was conducted on 208 patients with Lymphadenopathy who underwent FNAC in our institute. Hypocellular slides were excluded from the study. Diagnostic accuracy was assessed by comparing the cytopathological diagnosis with subsequent histopathological results of excised lymph nodes wherever possible. The sensitivity, specificity, positive predictive value, negative predictive value and discordance rate were calculated.

There was male preponderance of cases. Out of 208 cases, 112 (53.8%) were benign, 76 (36.5%) were malignant and 20(9.6%) were unsatisfactory due to poor cell yield. 48 patients underwent biopsy and histopathological correlation was obtained. The results of FNAC were consistent with biopsy in all except for 4 cases. The overall diagnostic sensitivity, specificity, positive predictive value and negative predictive value of FNAC of peripheral lymphadenopathy were 80%, 100%, 100% and 90.3% respectively. The overall diagnostic accuracy was 88.4%, while the overall discordance rate was 11.6%.

The ease of FNAC along with high diagnostic accuracy makes it desirable for diagnosis for patients with peripheral lymphadenopathy.

Keywords

FNAC, Histopathology, Lymphadenopathy