Clinico-Cytohistopathological evaluation of Skin Lesions with Special Reference to Bullous Lesions in hapur Region

Cytopathology of skin has been documented to be useful in the diagnosis of several skin lesions. The present study was conducted to correlate the clinical diagnosis with cytology and histopathology for the diagnosis of various nodular inflammatory lesions.

This study aims to evaluate cytopathology as a quick non-invasive method for early diagnosis of bullous lesions, neoplastic and preneoplastic skin lesions and to correlate the clinical, cytological and histopathological findings of various skin lesions.

The study was retrospective hospital based study carried out over a period of 3 year in which 170 patients of skin lesions were included in the study. Skin scraping, Tzanck smears, slit smears and fine needle aspiration cytology (FNAC) were done to obtain material for cytological examination. Excisional biopsy, incisional biopsy and punch biopsy were done to obtain tissue for histopathological examination. The slides were stained with routine stains and special stains as and when required.

Out of the 170 patients, 90 were males and 80 females. The most common non-neoplastic lesions observed were vesico-bullous lesions which comprised of 82 cases followed by neoplastic lesions which consisted of 48 cases, of which 12 were benign and 36 malignant. Concordant results between cytology and histopathology was seen in majority (91.7%) of lesions studied.

Cytology (scrape/imprint/slit smears and FNAC), performed skillfully and with perfection, leads to an early diagnosis in majority of the lesions, as the observed cytomorphological features of various skin lesions were fairly distinctive making cytology a fairly sensitive ‘patient compliant’ technique for rapid diagnosis of skin lesions.