1Professor, Department of Pathology, Saraswathi Institute of Medical Sciences, Hapur (U.P.)
2Demonstrator, Department of Pathology, Saraswathi Institute of Medical Sciences, Hapur (U.P.)
3Post Graduate IInd Year, Department of Pathology, Saraswathi Institute of Medical Sciences, Hapur (U.P.)
*Corresponding author: Dr. Jay Kant Jha Professor, Department of Pathology, Saraswathi Institute of Medical Sciences, Hapur (U.P.) Email: ankitpathology@gmail.com Mob.: 7078334783
Online published on 6 September, 2018.
Micropapillomas/papillomas and complex sclerosing lesions of the breast have been asso-ciated with a slightly increased risk for subsequent carcinoma, although benign squamous metaplasia and reactive hypercellular stroma are seen within these lesions. There are few reports of these fibrosclerotic lesions associated with metaplastic tumors.
To assess the describe a series of metaplastic tumors arising within fibrosclerotic breast lesions.
A retrospective study over a period of 3 year, breast aspirates who attended the surgery outpatient department in Saraswathi institute of medical sciences and hospital from July 2010 to June 2013, thirty-three metaplastic tumors associated with fibrosclerotic lesions were selected from a breast pathology consultative practice. Relevant clinical and pathological features were reviewed.
Both the metaplastic component (spindled and squamous cells) and the glandular elements were graded. The metaplastic tumors arose within papillomas (20 cases), complex sclerosing lesions (7 cases), both papilloma and complex sclerosing lesions (3 cases), and nipple adenoma (3 cases). A majority of the metaplastic tumors showed a dominant spindle cell component with various degrees of atypia, ranging from fibromatosis-like (16 cases) to low-grade (13 cases), intermediate-grade (2 cases), and high-grade (2 cases) fibrosarcoma phenotype. Squamous metaplasia was present in 25 cases, and low-grade glandular elements, in 21 cases. Eleven tumors had a low-grade adenosquamous growth pattern. Ductal carcinoma in situ was present in 7 cases, and invasive mammary carcinoma, in 5 cases. The very low-grade tumors were histologi cally similar to limited areas of stromal reaction and myofibroblastic proliferation, seen in partially sclerotic micropapillomas/papillomas and complex sclerosing lesions, but usually more cellular.
Spindle cell metaplastic tumors, from fibromatosis-like to fibrosarcoma, may arise within a variety of fibrosclerotic breast lesions.
Breast lesion, Spindle cell, papilloma
